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| Decellularized and recellularized hearts as a therapeutic strategy for heart failure ： ウィキペディア英語版 |
Decellularized and recellularized hearts as a therapeutic strategy for heart failure
Heart failure is one of the leading causes of death.〔 Often, the only viable treatment for end-stage heart failure is organ transplantation.〔 Currently organ supply is insufficient to meet the demand, which presents a large limitation in an end-stage treatment plan.〔〔 A theoretical alternative to traditional transplantation processes is the engineering of personalized bioartificial hearts. Researchers have had many successful advances in the engineering of cardiovascular tissue and have looked towards using decellularized and recellularized cadaveric hearts in order to create a functional organ.〔 Decellularization-recellularization involves using a cadaveric heart, removing the cellular contents while maintaining the protein matrix (decellularization), and subsequently facilitating growth of appropriate cardiovascular tissue inside the remaining matrix (recellularization).〔
== Creating the Bioartificial Heart ==
The remaining ECM is composed of structural elements such as collagen, laminin, elastin and fibronectin. The ECM scaffold promotes proper cellular proliferation and differentiation, vascular development, as well as providing mechanical support for cellular growth.〔 Because minimal DNA material remains after the decellularization process, the engineered organ is biocompatible with the transplant recipient, regardless of species. Unlike traditional transplant options, recellularized hearts are less immunogenic and have a decreased risk of rejection.〔〔
Once the decellularized heart has been sterilized to remove any pathogens, the recellularization process can occur.〔 These MCPs are then added to the decellularized heart and with additional exogenous growth factors, are stimulated to differentiate into cardiomyocytes, smooth muscle cells and endothelial cells.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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